| pubmed-article:8349820 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0042960 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C1549078 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C1997894 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0019691 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0085432 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0475463 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:8349820 | lifeskim:mentions | umls-concept:C1519888 | lld:lifeskim |
| pubmed-article:8349820 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8349820 | pubmed:dateCreated | 1993-9-15 | lld:pubmed |
| pubmed-article:8349820 | pubmed:abstractText | Sera from 11 volunteers immunized with a recombinant HIV-1 gp160-expressing vaccinia virus (HIVAC-1e; Oncogen/Bristol-Myers Squibb, Seattle, WA) and boosted with baculovirus-derived rgp160 (VaxSyn; MicroGeneSys, Inc., Meriden, CT) were evaluated for functional serum antibodies and their epitopes. Sera obtained prior to boosting had undetectable HIV-1-specific IgG and neutralizing activity, and did not block HIV-1 from binding or fusing to CD4+ MT-2 cells. 14 d after boosting, sera from each volunteer contained HIV-1-specific IgG titers of 1:40 to 1:1,280. Five of these sera also contained neutralizing antibodies, where most or all neutralizing activity was blocked by a synthetic peptide corresponding to amino acids 307-330 of the V3 loop of gp120, indicating that neutralizing antibodies were mostly V3 loop-specific. All sera obtained after boosting contained HIV-1 binding/fusion-inhibition antibodies, and a significant portion of their activity was blocked by the V3 loop peptide, a result consistent with the presence of antibodies against the region of the V3 loop that participates in fusion. Three sera with V3 loop-specific neutralizing and fusion-inhibition antibodies were studied further. In competitive antibody binding experiments, antibodies reactive with the conformation-dependent, CD4 binding site of gp120 were undetectable in each serum. When evaluated in combination with a monoclonal antibody to the CD4 binding site of gp120, two sera demonstrated synergism in neutralizing assays, and all three sera demonstrated synergism in binding/fusion-inhibition assays, further indicating that the functional antibodies were primarily V3 loop-specific. The synergism also suggests that a vaccine that elicits strong serum antibody responses to both regions of gp120 may improve the potential for inducing protective immunity. | lld:pubmed |
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| pubmed-article:8349820 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8349820 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8349820 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8349820 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8349820 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8349820 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8349820 | pubmed:author | pubmed-author:GrahamB SBS | lld:pubmed |
| pubmed-article:8349820 | pubmed:author | pubmed-author:PosnerM RMR | lld:pubmed |
| pubmed-article:8349820 | pubmed:author | pubmed-author:SchwartzD HDH | lld:pubmed |
| pubmed-article:8349820 | pubmed:author | pubmed-author:ZhouJJ | lld:pubmed |
| pubmed-article:8349820 | pubmed:author | pubmed-author:MontefioriD... | lld:pubmed |
| pubmed-article:8349820 | pubmed:author | pubmed-author:CavaciniL ALA | lld:pubmed |
| pubmed-article:8349820 | pubmed:author | pubmed-author:BuccoR ARA | lld:pubmed |
| pubmed-article:8349820 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8349820 | pubmed:volume | 92 | lld:pubmed |
