Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-9-16
pubmed:abstractText
Mice with the recessive motheaten (me) or the allelic viable motheaten (mev) mutations express a severe autoimmune and immunodeficiency syndrome. We have shown that the basic defect in these mice involves lesions in the gene which encodes haematopoietic cell phosphatase (HCP). These mice thus provide excellent models for investigating the roles of phosphatases in haematopoiesis and the nature of the genetic and cellular events linking impaired haematopoiesis to severe immunodeficiency and expression of systemic autoimmunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1061-4036
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:geneSymbol
me<up>v</up>
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:8348149-Alopecia, pubmed-meshheading:8348149-Animals, pubmed-meshheading:8348149-Autoimmune Diseases, pubmed-meshheading:8348149-Base Sequence, pubmed-meshheading:8348149-Bone Marrow, pubmed-meshheading:8348149-Chromosome Mapping, pubmed-meshheading:8348149-Consensus Sequence, pubmed-meshheading:8348149-DNA Mutational Analysis, pubmed-meshheading:8348149-Genes, Recessive, pubmed-meshheading:8348149-Hematopoietic Stem Cells, pubmed-meshheading:8348149-Immunologic Deficiency Syndromes, pubmed-meshheading:8348149-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:8348149-Mice, pubmed-meshheading:8348149-Mice, Inbred C57BL, pubmed-meshheading:8348149-Mice, Mutant Strains, pubmed-meshheading:8348149-Molecular Sequence Data, pubmed-meshheading:8348149-Mutation, pubmed-meshheading:8348149-Phenotype, pubmed-meshheading:8348149-Phosphorylation, pubmed-meshheading:8348149-Polymerase Chain Reaction, pubmed-meshheading:8348149-Protein Processing, Post-Translational, pubmed-meshheading:8348149-Protein Tyrosine Phosphatase, Non-Receptor Type 6, pubmed-meshheading:8348149-Protein Tyrosine Phosphatases, pubmed-meshheading:8348149-RNA, Messenger, pubmed-meshheading:8348149-RNA Splicing, pubmed-meshheading:8348149-Sequence Alignment, pubmed-meshheading:8348149-Sequence Deletion
pubmed:year
1993
pubmed:articleTitle
Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene.
pubmed:affiliation
Toronto Hospital, Ontario, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't