| pubmed-article:8345430 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C0579233 | lld:lifeskim |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8345430 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8345430 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8345430 | pubmed:dateCreated | 1993-9-9 | lld:pubmed |
| pubmed-article:8345430 | pubmed:abstractText | Tumor necrosis factor alpha (TNF alpha) has been implicated as one of the major mediators of the gram-negative septic shock syndrome. In our studies, group B streptococci (GBS) induced the production of TNF alpha by human mononuclear cells in a dose- and time-dependent manner. Human mixed mononuclear cell cultures exposed to an encapsulated (657.6 +/- 71.3 pg/ml; n = 30 preparations) or an unencapsulated transposon mutant of type III GBS (755.8 +/- 54.7 pg/ml; n = 9) produced similar amounts of TNF alpha. Isolated monocytes and culture-derived macrophages produced higher amounts of TNF alpha (1565 +/- 211 and 1790 +/- 928 pg/ml respectively) in response to GBS than did mixed mononuclear cell cultures. In response to GBS, mixed mononuclear cells from neonates produced significantly more TNF alpha (729.1 +/- 45 vs 520.3 +/- 47.2 pg/ml; p = 0.004) than did cells from adults. Examination of specimens from patients with neonatal GBS disease revealed detectable levels of TNF alpha (7 to 424 pg/ml) in the serum of 5 of 10 patients with sepsis, in 5 of 5 urine samples from infants with sepsis, and in the cerebrospinal fluid of 1 patient with meningitis. These results suggest both a major role for TNF alpha in the pathogenesis of human neonatal GBS sepsis and shock and a potential role for immunotherapy directed against this cytokine in this fulminant neonatal bacterial infection. | lld:pubmed |
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| pubmed-article:8345430 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8345430 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8345430 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8345430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8345430 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8345430 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8345430 | pubmed:issn | 0022-3476 | lld:pubmed |
| pubmed-article:8345430 | pubmed:author | pubmed-author:WilliamsP APA | lld:pubmed |
| pubmed-article:8345430 | pubmed:author | pubmed-author:HoltN FNF | lld:pubmed |
| pubmed-article:8345430 | pubmed:author | pubmed-author:RubensC ECE | lld:pubmed |
| pubmed-article:8345430 | pubmed:author | pubmed-author:BohnsackJ FJF | lld:pubmed |
| pubmed-article:8345430 | pubmed:author | pubmed-author:AugustineN... | lld:pubmed |
| pubmed-article:8345430 | pubmed:author | pubmed-author:DrummondW KWK | lld:pubmed |
| pubmed-article:8345430 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8345430 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:8345430 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8345430 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8345430 | pubmed:pagination | 292-300 | lld:pubmed |
| pubmed-article:8345430 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8345430 | pubmed:meshHeading | pubmed-meshheading:8345430-... | lld:pubmed |
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| pubmed-article:8345430 | pubmed:meshHeading | pubmed-meshheading:8345430-... | lld:pubmed |
| pubmed-article:8345430 | pubmed:meshHeading | pubmed-meshheading:8345430-... | lld:pubmed |
| pubmed-article:8345430 | pubmed:meshHeading | pubmed-meshheading:8345430-... | lld:pubmed |
| pubmed-article:8345430 | pubmed:meshHeading | pubmed-meshheading:8345430-... | lld:pubmed |
| pubmed-article:8345430 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8345430 | pubmed:articleTitle | Production of tumor necrosis factor by human cells in vitro and in vivo, induced by group B streptococci. | lld:pubmed |
| pubmed-article:8345430 | pubmed:affiliation | Department of Pathology, University of Utah School of Medicine, Salt Lake City 84132. | lld:pubmed |
| pubmed-article:8345430 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8345430 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8345430 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8345430 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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