|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0033618,
umls-concept:C0036825,
umls-concept:C0040087,
umls-concept:C0086418,
umls-concept:C0229671,
umls-concept:C0243072,
umls-concept:C0439849,
umls-concept:C0441655,
umls-concept:C0445223,
umls-concept:C0598631,
umls-concept:C1280500,
umls-concept:C1533691,
umls-concept:C1552599,
umls-concept:C1611588,
umls-concept:C1704787
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1993-8-11
|
|
pubmed:abstractText |
Several derivatives of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) were examined for their inhibitory effects on the replication of human immunodeficiency virus type 1 (HIV-1) in MT-4 cells in the presence of various concentrations (10-50%) of human serum (HS). Although all HEPT derivatives proved to be highly potent inhibitors of HIV-1 in the presence of 10% fetal bovine serum, some of them were less inhibitory to HIV-1 replication in the presence of HS. The HEPT derivatives were found to be highly bound to HS proteins. Both the anti-HIV-1 activity and HS protein binding of the compounds appeared to be related to their lipophilicity.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0006-2952
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
22
|
|
pubmed:volume |
45
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
2507-12
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Effect of human serum on the in vitro anti-HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding.
|
|
pubmed:affiliation |
Department of Microbiology, Fukushima Medical College, Japan.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
