Linked Life Data

8328014

Source:http://linkedlifedata.com/resource/pubmed/id/8328014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-8-9
pubmed:abstractText
Tautomerism of nucleotides is an attractive model to explain transitional mutations; the structure of the mismatched base pairs in their enol or imino forms do not distort the DNA double helix. However recent structural data suggest that the mismatched nucleotides are in their normal keto and amino forms. 'Wobble' and other base pairings (for transversions) have C1'-C1' distances close to those found in the classical Watson-Crick base pairs. Kinetic studies show substrates are in their major tautomeric forms in their transition states. This suggests tautomerism may not be important for substitution mutations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0968-0004
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Base mismatches and mutagenesis: how important is tautomerism?
pubmed:affiliation
Department of Biochemistry, University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't