Linked Life Data

8323529

Source:http://linkedlifedata.com/resource/pubmed/id/8323529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-8-5
pubmed:abstractText
To clarify the role of angiotensin III (ANGIII) in inflammation, we examined the effect of ANGIII on the chemotaxis of human polymorphonuclear neutrophils (PMNs). The elicitation of PMN chemotaxis by ANGIII was dose dependent with an optimum dose of 10(-10) M. The time course for ANGIII-elicited chemotaxis showed a maximal level at 90 min, but N-formyl-Met-Leu-Phe (FMLP) elicited a maximal level of chemotaxis at 60 min. When ANGIII (10(-10) M) and FMLP (10(-7) M) were given in combination, the level of chemotaxis elicited was not significantly different from the levels attained with each peptide alone, suggesting that a similar pathway of signal transduction might be involved in the chemotaxis of PMNs elicited by ANGIII and FMLP. Thus, ANGIII is a new chemoattractant for PMNs that may use a signal transduction pathway similar to, but different from, that used by FMLP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
193
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1038-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Angiotensin III is a new chemoattractant for polymorphonuclear leukocytes.
pubmed:affiliation
Department of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Japan.
pubmed:publicationType
Journal Article, In Vitro