Linked Life Data

8322491

Source:http://linkedlifedata.com/resource/pubmed/id/8322491

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-7-30
pubmed:abstractText
Mice were injected with immune serum to vaccinia and/or influenza virus and then immunized by scarification with a recombinant vaccinia virus expressing the influenza haemagglutinin H1. The serum IgG antibody response to the foreign gene product, influenza H1, was suppressed by the passively administered anti-influenza antibody in a dose-dependent manner. Anti-vaccinia antibody alone had no effect on the anti-haemagglutinin antibody response to the recombinant vaccinia and did not suppress an anti-vaccinia antibody response. Secondary cytotoxic T-lymphocyte killing of influenza virus-infected target cells was relatively low in all animals that were immunized with the recombinant vaccinia, and showed some dose-dependent suppression by the passively administered antibody. The dose dependence of the inhibition suggests that while immunization with recombinant vaccinia viruses may not be effective at birth, they may be useful at several months of age.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0264-410X
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
665-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Recombinant vaccinia immunization in the presence of passively administered antibody.
pubmed:affiliation
Department of Medicine, University of Florida College of Medicine, Gainesville 32610-0266.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't