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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1993-7-23
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pubmed:abstractText |
Agents which prime the neutrophil NADPH oxidase develop during routine storage of whole blood and packed red blood cells. This plasma priming activity can be inhibited by bepafant (WEB 2170), a specific platelet activating factor (PAF) receptor antagonist. Quantitation of the priming agent(s), by a commercially available radioimmunoassay for PAF, reproducibly demonstrated high levels of PAF activity. However, analysis of these plasma samples from stored blood components by gas chromatography/mass spectroscopy did not reveal any 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine. We conclude that the polyclonal antibody to PAF used in these studies may have recognized different epitopes of a family of heterogeneous, biologically active lipids that manifest their effects through the PAF receptor.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Azepines,
http://linkedlifedata.com/resource/pubmed/chemical/NADH, NADPH Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/bepafant
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0024-4201
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
415-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8316049-Azepines,
pubmed-meshheading:8316049-Blood Preservation,
pubmed-meshheading:8316049-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:8316049-Humans,
pubmed-meshheading:8316049-NADH, NADPH Oxidoreductases,
pubmed-meshheading:8316049-NADPH Oxidase,
pubmed-meshheading:8316049-Neutrophils,
pubmed-meshheading:8316049-Platelet Activating Factor,
pubmed-meshheading:8316049-Radioimmunoassay,
pubmed-meshheading:8316049-Triazoles
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pubmed:year |
1993
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pubmed:articleTitle |
Compounds biologically similar to platelet activating factor are present in stored blood components.
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pubmed:affiliation |
Department of Pediatrics, University of Colorado School of Medicine, Denver.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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