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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-3-21
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pubmed:abstractText |
Major histocompatibility complex (MHC) class II antigens consist of alpha and beta chains that associate intracellularly with the invariant (I) chain. The HLA-DR alpha beta I complex assembles in the endoplasmic reticulum (ER) into a nonameric structure via progressive addition of three alpha beta dimers to a core invariant chain trimer. We have examined intracellular association of alpha beta I complexes with the resident ER protein calnexin. Calnexin associates rapidly (within 3 min) with newly synthesized alpha, beta and I chains, and remains associated with the assembling alpha beta I complex until the final alpha beta dimer is added, forming the complete nonamer. Dissociation of calnexin parallels egress of alpha beta I from the ER. These results suggest that calnexin retains and stabilizes both free class II subunits and partially assembled class II-I chain complexes until assembly of the nonamer is complete.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1311249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1315422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1317713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1326756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1329208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1336670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1349157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1350281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1373173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1400441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1512535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1549594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1568250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1584811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1588042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1588286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1692393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1731198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1891045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1900941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1913812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1918067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1956401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-1999467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2068076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2121367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2157712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2190094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2234057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2250716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2295824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-23215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2391366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-2738090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-3084497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-3095828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-3287381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-3464691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-567555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-6166872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-6185348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-6611328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-6955026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-6966655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-6982931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-7679955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-8098731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-8419482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-8456316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8313912-8486646
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
675-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1994
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pubmed:articleTitle |
A role for calnexin (IP90) in the assembly of class II MHC molecules.
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pubmed:affiliation |
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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