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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1994-3-21
|
| pubmed:abstractText |
Spontaneously hypertensive (SH) rats immunized with mouse renin produce anti-renin antibodies, responsible for down-modulation of blood pressure, associated with an infiltration of kidneys by mononuclear cells. In this work, anti-renin T cells from SH rats immunized with renin have been stimulated in vitro, and we have studied in vitro and in vivo their effect on anti-renin antibody production by normal syngeneic B cells. We show that, in vitro, renin-activated T cells induce a renin-specific antibody response without addition of exogenous renin. Anti-renin T cells injected into naive SH rats trigger normal B cells to secrete high amounts of monospecific anti-renin IgG antibodies as early as day 5. These antibodies interfere with the homeostasis of the renin-angiotensin system leading to the normalization of blood pressure without any nephritis. These results show that anti-renin B cells are either not tolerant per se or in a reversible state of anergy. Our results also suggest that anti-renin B cells constitutively express renin-derived peptides in such a way that they may be stimulated by activated anti-renin T cells; these cells express IL-4 mRNA indicating that IL-4 could play a role in the differentiation of B cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0953-8178
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1569-76
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8312227-Animals,
pubmed-meshheading:8312227-Antibody Formation,
pubmed-meshheading:8312227-B-Lymphocytes,
pubmed-meshheading:8312227-Base Sequence,
pubmed-meshheading:8312227-Cell Communication,
pubmed-meshheading:8312227-Cells, Cultured,
pubmed-meshheading:8312227-Flow Cytometry,
pubmed-meshheading:8312227-Hypertension,
pubmed-meshheading:8312227-Immunization,
pubmed-meshheading:8312227-Interferon-gamma,
pubmed-meshheading:8312227-Interleukin-2,
pubmed-meshheading:8312227-Lymphocyte Activation,
pubmed-meshheading:8312227-Male,
pubmed-meshheading:8312227-Molecular Sequence Data,
pubmed-meshheading:8312227-Ovalbumin,
pubmed-meshheading:8312227-Rats,
pubmed-meshheading:8312227-Rats, Inbred SHR,
pubmed-meshheading:8312227-Renin,
pubmed-meshheading:8312227-T-Lymphocytes
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Anti-renin T cells trigger normal B cells to produce anti-renin antibodies and normalize blood pressure in spontaneously hypertensive rats.
|
| pubmed:affiliation |
INSERM U28, Hôpital Broussais, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|