Linked Life Data

8306422

Source:http://linkedlifedata.com/resource/pubmed/id/8306422

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-3-17
pubmed:abstractText
We have used in situ hybridization to study the distribution of mRNA for neuropeptide Y (NPY), peptide YY (PYY) and the NPY/PYY receptor of the Y1 subtype during ontogenesis in the rat and immunohistochemistry to analyse peptide immunoreactivity for NPY and PYY. We found that mRNA and immunoreactivity for NYY are transiently expressed in dorsal root ganglia (DRG) at embryonic day 16 (E16). In contrast, neither NPY mRNA nor NPY-like immunoreactivity were found in DRG at any developmental stage. The Y1 receptor mRNA is not expressed in DRG at E16 but it appears in these ganglia later in development (E20) and it is present in DRG of adult rats. In sagittal sections of whole embryos at very early stages of development we found that the onset of PYY mRNA expression is around day 11, when mRNA for PYY is found in the foregut. NPY and Y1-receptor mRNA are not detected in whole embryo sections until around day 14. Therefore, PYY mRNA expression precedes by 2-3 days the expression of mRNA for both NPY and the Y1 receptor. At E14, PYY mRNA is present in trigeminal ganglia and stomach. Our results suggest that PYY is not only a gut hormone but may also act as a neuropeptide with roles in the development of sensory neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Expression of peptide YY and mRNA for the NPY/PYY receptor of the Y1 subtype in dorsal root ganglia during rat embryogenesis.
pubmed:affiliation
Department of Medical Genetics, Uppsala University, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't