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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-3-8
|
| pubmed:abstractText |
Microglial cells are resident immunoeffector cells of the central nervous system. They differ from most other resident macrophages by their ramified shape, their capacity to proliferate, and by a distinct pattern of ion channels. They have therefore been proposed to be a subpopulation of macrophages that arise from a distinct pool of myelomonocytes by early determination of their lineage within the bone marrow. Here we present data which show that distinct properties of the microglial cells are not intrinsic to this subpopulation of macrophages, but are acquired subsequent to their interaction with astroglial cells, since similar properties can be induced in both blood monocytes and spleen macrophages, when these are cultured on astrocytes. These findings add further evidence to the proposition that microglial cells are derived from the myelomonocytic lineage, and also indicate that the properties of resident macrophages are largely determined by tissue components of the host organ.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0940-9602
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
176
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
45-51
|
| pubmed:dateRevised |
2005-5-18
|
| pubmed:meshHeading |
pubmed-meshheading:8304591-Animals,
pubmed-meshheading:8304591-Animals, Newborn,
pubmed-meshheading:8304591-Astrocytes,
pubmed-meshheading:8304591-Cell Communication,
pubmed-meshheading:8304591-Cell Differentiation,
pubmed-meshheading:8304591-Cells, Cultured,
pubmed-meshheading:8304591-Culture Media, Conditioned,
pubmed-meshheading:8304591-Electric Stimulation,
pubmed-meshheading:8304591-Fibronectins,
pubmed-meshheading:8304591-Glial Fibrillary Acidic Protein,
pubmed-meshheading:8304591-Histocytochemistry,
pubmed-meshheading:8304591-Liver,
pubmed-meshheading:8304591-Macrophages,
pubmed-meshheading:8304591-Membrane Potentials,
pubmed-meshheading:8304591-Microglia,
pubmed-meshheading:8304591-Monocytes,
pubmed-meshheading:8304591-Potassium Channels,
pubmed-meshheading:8304591-Rats,
pubmed-meshheading:8304591-Spleen
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Blood monocytes and spleen macrophages differentiate into microglia-like cells when cultured on astrocytes.
|
| pubmed:affiliation |
Department of Anatomy, University of Kiel, Germany.
|
| pubmed:publicationType |
Journal Article
|