Linked Life Data

8302246

Source:http://linkedlifedata.com/resource/pubmed/id/8302246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-3-9
pubmed:abstractText
The three-dimensional distribution of neuronal heterotopiae induced in rat brains by prenatal exposure to the cytotoxic drug, methylazoxymethanol acetate, has been examined by computer reconstruction techniques. Three types of heterotopiae may be identified in mature rat brains exposed between E11 and E16: Layer I heterotopiae, periventricular heterotopiae, and hippocampal heterotopiae. The distributions of Layer I heterotopiae and periventricular heterotopiae show clear temporospatial gradients; such that with subsequent age of exposure, Layer I heterotopiae are situated progressively more medially, dorsally, and rostrally, and periventricular heteotopiae are situated progressively more rostrally. Periventricular heterotopiae are most extensive following exposure to the agent on E14. For both of these heterotopiae there is a characteristic pattern of distribution for each gestational age of exposure to the agent. By contrast, hippocampal heterotopiae, consisting of misplaced pyramidal neurons in subfields CA1 and CA2 of Ammon's horn, did not show significant changes in distribution with different ages of exposure to the drug. The significance of these temporospatial gradients for mechanisms underlying the production of the heterotopiae is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0892-0362
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
439-44
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:articleTitle
Distribution of neuronal heterotopiae following prenatal exposure to methylazoxymethanol.
pubmed:affiliation
School of Anatomy, University of NSW, Kensington, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't