Linked Life Data

8301263

Source:http://linkedlifedata.com/resource/pubmed/id/8301263

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-3-7
pubmed:abstractText
Olfactory neurons respond to odors with a change in conductance that mediates an influx of cations including Ca2+. The concomitant increase in [Cai] has been postulated to play a role in the adaptation to maintained odorant stimulation (Kurahashi, T., and T. Shibuya. 1990. Brain Research. 515:261-268. Kramer, R. H., and S. A. Siegelbaum. 1992. Neuron. 9:897-906. Zufall, F., G. M. Shepherd, and S. Firestein. 1991. Proceedings of the Royal Society of London, B. 246:225-230.) We have imaged the distribution of [Cai] in rat olfactory neurons (RON) using the Ca2+ indicator fura-2. A large percentage of the RON (42%, n = 35) responded to odorants with an increase in [Cai]. About half of the responding neurons displayed an increase in [Cai] at the apical end of the cell, but not at the soma. Moreover, in those cells that responded to odors with a standing [Cai] gradient, the gradient could be maintained for long periods of time (minutes) provided that the cells were continuously stimulated. In contrast, K(+)-induced depolarization elicited a more homogeneous increase in [Cai]. The spatially inhomogeneous increase in [Cai] elicited by odorants in some cells has important implications for the role of Ca2+ in adaptation because channels and enzymes regulated by Ca2+ will be affected differently depending on their location.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1295
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
907-24
pubmed:dateRevised
2008-11-20
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Odorant-regulated Ca2+ gradients in rat olfactory neurons.
pubmed:affiliation
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.