Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-3-4
|
| pubmed:abstractText |
A total of 130 children diagnosed as having pulmonary and extrapulmonary tuberculosis who received short course intermittent chemotherapy between 1978-1992 were evaluated retrospectively. One hundred and ten children with tuberculosis were treated with isoniazid (10-15 mg/kg, maximum 400 mg), rifampin (10-15 mg/kg, maximum 600 mg), and streptomycin (30 mg/kg, maximum 1 g) daily, for 15 days. Treatment was completed with similar doses of isoniazid and rifampin twice a week for a period of 9 months. Since 1986, 20 children with tuberculosis were being treated with the same regimen but without streptomycin. The majority of patients in these cases had pulmonary tuberculosis (75%), followed by lymph nodes (9%), pleural (7%), bone and joint (5%), miliary (3%), and abdominal tuberculosis (1%). The clinicoradiologic response to treatment was observed to be excellent. Only one case of relapse was detected, which was the case of a patient with lymph node tuberculosis that occurred 18 months after the completion of treatment. No serious adverse drug reaction was observed in any of the cases mentioned. In conclusion, short-course low-dose intermittent chemotherapy is an effective and economical treatment with minimal side effects for pulmonary and extrapulmonary tuberculosis in childhood.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-8126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
324-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8300251-Adolescent,
pubmed-meshheading:8300251-Child,
pubmed-meshheading:8300251-Child, Preschool,
pubmed-meshheading:8300251-Drug Therapy, Combination,
pubmed-meshheading:8300251-Female,
pubmed-meshheading:8300251-Follow-Up Studies,
pubmed-meshheading:8300251-Humans,
pubmed-meshheading:8300251-Infant,
pubmed-meshheading:8300251-Isoniazid,
pubmed-meshheading:8300251-Male,
pubmed-meshheading:8300251-Rifampin,
pubmed-meshheading:8300251-Streptomycin,
pubmed-meshheading:8300251-Tuberculosis
|
| pubmed:articleTitle |
Short course intermittent chemotherapy in childhood tuberculosis.
|
| pubmed:affiliation |
Dept. of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
|
| pubmed:publicationType |
Journal Article
|