Linked Life Data

8297117

Source:http://linkedlifedata.com/resource/pubmed/id/8297117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6A
pubmed:dateCreated
1994-2-28
pubmed:abstractText
The present study was designed to investigate the factor of timing of activity onset in determining the effects of exercise on experimental metastases. After 9 weeks of wheel running activity (W) or remaining sedentary (S), male C3H/He mice received an i.v. injection of CIRAS 1 tumor cells. Mice were then randomized into sedentary and wheel running groups (SS, SW, WS, WW) for a further 3 weeks. Although the average number of lung tumours did not differ by activity condition, the groups exercised prior to tumour injection had a greater incidence in the lowest tertile of tumour distribution relative to sedentary controls (SS = 8/20 vs. WS = 16/19, p < 0.005; SS vs. WW = 14/18, p < 0.05). In a replication trial, a similar outcome was present in the lowest tertile: increased incidence of animals exercised prior to injection (SS = 3/9 vs. WW = 7/9: p < 0.05). These data suggest that exercise training before, but not after, i.v. exposure to tumour reduces the number of lung metastases and that the timing of exercise onset influences the extent of experimental metastasis in this model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2085-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Exercise training and tumour metastasis in mice: influence of time of exercise onset.
pubmed:affiliation
Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't