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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-3-2
|
| pubmed:abstractText |
We assessed the pattern of hepatitis C viremia in chronic liver disease by studying 100 hepatitis C virus antibody-positive patients: 48 with chronic hepatitis, 21 with cirrhosis and 31 with hepatocellular carcinoma and cirrhosis. Serum hepatitis C virus RNA was detected by means of both the conventional nested polymerase chain reaction and a newly developed assay based on branched DNA that can also quantify viremia. Hepatitis C virus RNA was found in 94 of 100 patients with polymerase chain reaction and in 71 of 100 patients with branched-DNA (p < 0.001). Mean viremia level (x 10(3) genome equivalents/ml +/- S.D.), as assessed with the branched-DNA test, was 5,700 +/- 7,618 in the 48 patients with chronic hepatitis, 3,340 +/- 3,633 in the 21 patients with cirrhosis and 1,768 +/- 2,770 in the 31 patients with hepatocellular carcinoma (p < 0.02). We also analyzed retrospectively the relationship between viremia and treatment. Fifty-five patients (41 chronic hepatitis, 14 cirrhosis) underwent interferon-alpha treatment. Mean viremia level was comparable among the 30 responders (5,644 +/- 8,207) and the 25 nonresponders (5,519 +/- 6,208) to interferon, but it was significantly lower (1,841 +/- 1,864) in the 12 of 30 responders (11 chronic hepatitis, 1 cirrhosis) who maintained remission up to 1 yr after cessation of interferon treatment. Fourteen patients (7 chronic hepatitis, 7 cirrhosis) with autoantibodies (12 antinuclear, 2 anti-liver-kidney microsomal) were treated with prednisone. The mean viremia level significantly increased after 3 mo of treatment, even in face of ALT decrease.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisone,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2b
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0270-9139
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
273-9
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8294085-Adult,
pubmed-meshheading:8294085-Alanine Transaminase,
pubmed-meshheading:8294085-Carcinoma, Hepatocellular,
pubmed-meshheading:8294085-Chronic Disease,
pubmed-meshheading:8294085-DNA, Viral,
pubmed-meshheading:8294085-Female,
pubmed-meshheading:8294085-Hepacivirus,
pubmed-meshheading:8294085-Hepatitis C,
pubmed-meshheading:8294085-Humans,
pubmed-meshheading:8294085-Interferon-alpha,
pubmed-meshheading:8294085-Liver Cirrhosis,
pubmed-meshheading:8294085-Liver Neoplasms,
pubmed-meshheading:8294085-Male,
pubmed-meshheading:8294085-Middle Aged,
pubmed-meshheading:8294085-Polymerase Chain Reaction,
pubmed-meshheading:8294085-Prednisone,
pubmed-meshheading:8294085-RNA, Viral,
pubmed-meshheading:8294085-Recombinant Proteins,
pubmed-meshheading:8294085-Retrospective Studies,
pubmed-meshheading:8294085-Viremia
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Hepatitis C viremia in chronic liver disease: relationship to interferon-alpha or corticosteroid treatment.
|
| pubmed:affiliation |
Clinica Medica R, University of Palermo, Italy.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|