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rdf:type |
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lifeskim:mentions |
umls-concept:C0014499,
umls-concept:C0015219,
umls-concept:C0017337,
umls-concept:C0025011,
umls-concept:C0028612,
umls-concept:C0080194,
umls-concept:C0205409,
umls-concept:C0220823,
umls-concept:C0331858,
umls-concept:C0332185,
umls-concept:C1704640,
umls-concept:C1706515
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pubmed:issue |
2
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pubmed:dateCreated |
1994-2-24
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01974,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01975,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01976,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01977,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01978,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01979,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01980,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01982,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01983,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01984,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01985,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01986,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01987,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01988,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01989,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U0198I,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01990,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01991,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01992,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01993,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01994,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01995,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01996,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01997,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01998,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U01999
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pubmed:abstractText |
To characterize the genetic properties of currently circulating strains of wild-type measles viruses, we constructed and sequenced cDNA clones of the nucleoprotein (N) and matrix (M) genes of wild-type strains isolated between 1958 and 1989. The N and M genes of wild-type isolates from the prevaccine era (before 1964) were highly related to each other and to the N and M genes of a currently used measles vaccine strain, Moraten. The N and M genes of these viruses differed by no more than 0.5% at the nucleotide level. In contrast, the N and M genes of wild-type viruses isolated between 1977 and 1989 showed genetic drift, with the greatest amount of drift occurring in the viruses isolated from recent cases in the United States. Overall, the M genes were slightly more conserved at the nucleotide level (2.6% nucleotide, 3.3% amino acid) than the N genes (4.8% nucleotide, 3.4% amino acid). Alignment of the predicted protein sequences of the N genes revealed two regions of amino acid heterogeneity. The evolutionary patterns for the N and M genes suggested that the wild-type viruses isolated in the United States in 1989 were more related to wild-type viruses isolated in the United Kingdom between 1983 and 1988 than to viruses isolated in the United States in 1983.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
198
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
724-30
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8291252-Amino Acid Sequence,
pubmed-meshheading:8291252-Base Sequence,
pubmed-meshheading:8291252-Biological Evolution,
pubmed-meshheading:8291252-Capsid,
pubmed-meshheading:8291252-Disease Outbreaks,
pubmed-meshheading:8291252-Genes, Viral,
pubmed-meshheading:8291252-Humans,
pubmed-meshheading:8291252-Measles,
pubmed-meshheading:8291252-Measles virus,
pubmed-meshheading:8291252-Molecular Sequence Data,
pubmed-meshheading:8291252-Sequence Analysis,
pubmed-meshheading:8291252-Sequence Homology, Amino Acid,
pubmed-meshheading:8291252-Viral Core Proteins,
pubmed-meshheading:8291252-Viral Matrix Proteins,
pubmed-meshheading:8291252-Viral Structural Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
Evolution of the nucleoprotein and matrix genes of wild-type strains of measles virus isolated from recent epidemics.
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pubmed:affiliation |
Respiratory and Enterovirus Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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