| pubmed-article:8284209 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C0812246 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C0072461 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C1149367 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:8284209 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8284209 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:8284209 | pubmed:dateCreated | 1994-2-14 | lld:pubmed |
| pubmed-article:8284209 | pubmed:abstractText | Thrombomodulin (TM) is expressed on vascular endothelial cells and plays an important role in the anticoagulant pathway by maintaining the thrombo-resistance of the blood vessel wall. We show that in primary human endothelial cells TM gene expression is repressed at the transcriptional level by Tumour necrosis factor (TNF alpha) through a protein kinase C independent pathway. The TM promoter is highly active in endothelial cells and is inhibited by TNF alpha. The -76/-56 region mediates both specific high basal activity and TNF alpha-repression. It binds a nuclear factor specific to endothelial cells, that appears to belong to the Ets-family by various criteria. The -76/-56 region contains three direct repeats of the ets-core sequence GGAA that are important for specific high basal activity, TNF alpha repression and trans-activation by expression of Ets-1 and 2. Although human Ets-1 (h-Ets-1) and chicken c-Ets-1 and 2 stimulate the TM promoter through the -76/-56 element, their activity is not suppressed by TNF alpha. c-Ets-1 competes and overrides TNF alpha repression in a concentration dependent manner. We propose that either a different member of the Ets domain protein family, or an Ets-associated co-factor, is the target of the TNF alpha signalling cascade in endothelial cells. | lld:pubmed |
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| pubmed-article:8284209 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8284209 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8284209 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8284209 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8284209 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8284209 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:8284209 | pubmed:author | pubmed-author:KunzCC | lld:pubmed |
| pubmed-article:8284209 | pubmed:author | pubmed-author:OtteJJ | lld:pubmed |
| pubmed-article:8284209 | pubmed:author | pubmed-author:WasylykBB | lld:pubmed |
| pubmed-article:8284209 | pubmed:author | pubmed-author:NischanCC | lld:pubmed |
| pubmed-article:8284209 | pubmed:author | pubmed-author:von der AheDD | lld:pubmed |
| pubmed-article:8284209 | pubmed:author | pubmed-author:KniesUU | lld:pubmed |
| pubmed-article:8284209 | pubmed:author | pubmed-author:OderwaldHH | lld:pubmed |
| pubmed-article:8284209 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8284209 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:8284209 | pubmed:volume | 21 | lld:pubmed |
