| pubmed-article:8283037 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C1412841 | lld:lifeskim |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C0032112 | lld:lifeskim |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C0221026 | lld:lifeskim |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8283037 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8283037 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8283037 | pubmed:dateCreated | 1994-2-14 | lld:pubmed |
| pubmed-article:8283037 | pubmed:abstractText | The gene mutated in the human disease, X-linked agammaglobulinemia (XLA), is related to the Src gene family of cytoplasmic protein-tyrosine kinases and is designated Btk (Bruton's agammaglobulinemia tyrosine kinase; formerly Atk/Bpk; the human gene is denoted BTK, using capital letters according to the kinase nomenclature). We have recently reported that this gene is expressed in B lymphocytes and that the specific mRNA was undetectable in T cells using Northern blotting. Further analyses of different sources of B and T lymphocytes confirmed this pattern. However, BTK transcripts were undetectable in four plasmacytoma lines. Moreover, as virtually normal amounts of BTK transcripts were found in PBMC from two patients carrying a point mutation in BTK, despite low B cell numbers, we anticipated that the gene would also be expressed in cells of other lineages. The erythroleukemia cell line K-562, the promyelocytic line HL-60 and the histiocytic lymphoma line U-937 were found to have BTK mRNA levels comparable to B cells. BTK mRNA was also detected in monocytes from healthy donors as well as in the human immature basophilic cell line KU812, in the human mast cell leukemia cell line HMC-1 and in the CD34 expressing myeloblast KG-1. A similar expression pattern was obtained when BTK protein was analyzed by immunoprecipitation and Western blotting. Using a polymerase chain reaction-based analysis, a small amount (less than 1% of the level in B cells) of BTK mRNA was identified in T lymphocytes. Our findings are compatible with a general expression of the BTK gene in hematopoietic cells, except in T lymphocytes and plasma cells, in which the transcript level is selectively down-regulated. | lld:pubmed |
| pubmed-article:8283037 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8283037 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8283037 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8283037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8283037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8283037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8283037 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8283037 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8283037 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:HammarströmLL | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:SmithC ICI | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:ChristenssonB... | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:LambrisJ DJD | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:OlssonP GPG | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:ManiarH SHS | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:ZhouJ NJN | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:BaskinBB | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:Humire-Greiff... | lld:pubmed |
| pubmed-article:8283037 | pubmed:author | pubmed-author:KjellénPP | lld:pubmed |
| pubmed-article:8283037 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8283037 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8283037 | pubmed:volume | 152 | lld:pubmed |
| pubmed-article:8283037 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8283037 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8283037 | pubmed:pagination | 557-65 | lld:pubmed |
| pubmed-article:8283037 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8283037 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8283037 | pubmed:articleTitle | Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells. | lld:pubmed |
| pubmed-article:8283037 | pubmed:affiliation | Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge, Sweden. | lld:pubmed |
| pubmed-article:8283037 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8283037 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:695 | entrezgene:pubmed | pubmed-article:8283037 | lld:entrezgene |
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