Linked Life Data

8272377

Source:http://linkedlifedata.com/resource/pubmed/id/8272377

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-1-31
pubmed:abstractText
A method is described to activate the systolic rise of [Ca2+]i in only one region of a single, isolated cell. This is achieved by applying the calcium chelator BAPTA to the rest of the cell from a pipette. Under control conditions electrical stimulation produced a Ca transient which was uniform throughout the cell. If a BAPTA containing solution was applied to one region of the cell for 100-500 ms before stimulation then there was no systolic Ca transient in that region of the cell. In the rest of the cell, however, the Ca transient was identical to that in control conditions. If BAPTA application was discontinued the Ca transient was normal throughout the cell on the next stimulation. In the presence of ouabain the locally activated systolic Ca transient propagated through the cell. Propagation was associated with an increase of systolic but not diastolic [Ca2+]i. These results show that the systolic Ca transient propagates if the cell Ca content is elevated. We suggest that the fact that Ca-overload produces spontaneous Ca release may be due to the fact that it allows spontaneous Ca release (which may always be occurring) to propagate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
425
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-3
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes.
pubmed:affiliation
Department of Veterinary Preclinical Sciences, University of Liverpool, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't