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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1994-1-21
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pubmed:abstractText |
T cells which recognize antigen in association with self major histocompatibility complex (MHC) molecules are positively selected within the thymus. This results in skewing of the T-cell repertoire toward the recognition of antigenic peptides presented by self MHC molecules. While the thymus gland involutes at a relatively young age, bone marrow function and the size of the peripheral T-cell pool are maintained with age. We have investigated the MHC restriction of helper T-cell function for B-cell production of specific antibody in mice of different ages. Splenic helper T cells from 2- to 3-month old mice immunized with phosphocholine-keyhole limpet hemocyanin conjugate were MHC-restricted as defined by their capacity to induce phosphocholine-specific antibody synthesis by syngeneic but not by allogeneic B cells. In contrast, splenic T cells from immunized 18- to 20-month-old mice induced specific anti-phosphocholine antibodies by both syngeneic and allogeneic B cells. No evidence of polyclonal immunoglobulin synthesis was detected. The ability of T cells from old mice immunized with phosphocholine-keyhole limpet hemocyanin to induce phosphocholine-specific antibody synthesis by B cells from allogeneic mice was inhibited by T cells from immunized young mice. These findings suggest that non-MHC-restricted T-cell helper activity in old mice results from the loss of T cells, present in young mice, which suppress non-MHC-restricted helper cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-1082098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-1093401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-1425923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2185329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2379238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2477705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2479692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2528072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2543585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2571938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2594068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2784868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2788280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2846743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2950524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-2965649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-3093894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-310857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-315070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-3155996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-3280468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-3487615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-3720820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-4133084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-4139235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-4563336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-46913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-5059886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6181895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-62009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6206137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6222139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6235179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6445918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6792318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-68474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6968781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-6998260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-7013988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8265615-7024406
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11718-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8265615-Aging,
pubmed-meshheading:8265615-Animals,
pubmed-meshheading:8265615-Antigens, Surface,
pubmed-meshheading:8265615-B-Lymphocytes,
pubmed-meshheading:8265615-Cells, Cultured,
pubmed-meshheading:8265615-Female,
pubmed-meshheading:8265615-Hemocyanin,
pubmed-meshheading:8265615-Immunization,
pubmed-meshheading:8265615-Immunophenotyping,
pubmed-meshheading:8265615-Major Histocompatibility Complex,
pubmed-meshheading:8265615-Mice,
pubmed-meshheading:8265615-Mice, Inbred BALB C,
pubmed-meshheading:8265615-Mice, Inbred C3H,
pubmed-meshheading:8265615-Mice, Inbred C57BL,
pubmed-meshheading:8265615-Mollusca,
pubmed-meshheading:8265615-Phosphorylcholine,
pubmed-meshheading:8265615-T-Lymphocytes,
pubmed-meshheading:8265615-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1993
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pubmed:articleTitle |
Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.
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pubmed:affiliation |
Department of Medicine, Cornell University Medical College, New York, NY 10021.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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