rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
1994-1-26
|
pubmed:abstractText |
Allele and genotype frequencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types--available for all the studied samples--allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage analysis of genetic disorders mapping on this region of 6p.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0890-8508
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
411-4
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8264675-Alleles,
pubmed-meshheading:8264675-Base Sequence,
pubmed-meshheading:8264675-Chromosome Mapping,
pubmed-meshheading:8264675-Chromosomes, Human, Pair 6,
pubmed-meshheading:8264675-DNA, Satellite,
pubmed-meshheading:8264675-DNA Primers,
pubmed-meshheading:8264675-Female,
pubmed-meshheading:8264675-Genetic Markers,
pubmed-meshheading:8264675-HLA-A Antigens,
pubmed-meshheading:8264675-Humans,
pubmed-meshheading:8264675-Italy,
pubmed-meshheading:8264675-Male,
pubmed-meshheading:8264675-Molecular Sequence Data,
pubmed-meshheading:8264675-Polymerase Chain Reaction,
pubmed-meshheading:8264675-Recombination, Genetic,
pubmed-meshheading:8264675-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:8264675-Telomere
|
pubmed:year |
1993
|
pubmed:articleTitle |
Construction of a genetic map telomeric to HLA-A by microsatellite analysis.
|
pubmed:affiliation |
Dipartimento Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|