Linked Life Data

8255668

Source:http://linkedlifedata.com/resource/pubmed/id/8255668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-1-10
pubmed:abstractText
Over the last 10 years, the explosion of molecular biology and molecular genetic techniques have allowed major advances in the diagnosis and management of a wide variety of human disorders. These range from accurate and simple screening for carriers of thalassemia (Old JM, Varawalla NY, Weatherall DJ: Lancet 2:834-837, 1990) to the use of preimplantation diagnosis of embryos at risk for untreatable congenital defects (Monk M, Holding C: Lancet 1:985-988, 1990) and the development of gene therapy for treatment of disorders such as adenosine deaminase deficiency (Sharp D: Lancet 1:1277-1278, 1991). These same molecular techniques have also been applied to pediatric lipid disorders with some notable successes, both in their diagnosis and understanding the mechanisms of the resulting pathology, including the recent experiments (Wilson JM, Grossman M, Wu CH, Chowdhury NR, Wu GY, Chowdhury JR: J Biol Chem 267:963-967, 1992) that have led to proposals to treat homozygous familial hypercholesterolemia by gene therapy. The purpose of this review is to detail this molecular genetic progress for two of the disorders that result in disturbed triglyceride metabolism in infants, lipoprotein lipase deficiency and apo CII deficiency, and four disorders that lead to disturbed cholesterol levels in infancy, abetalipoproteinemia, hypobetalipoproteinemia, familial defective apo B, and familial hypercholesterolemia. We will also address the question of how knowledge of the mutation causing the defect in a particular patient could be clinically useful and highlight areas of research for the future.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-15
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The molecular genetics of pediatric lipid disorders: recent progress and future research directions.
pubmed:affiliation
Centre for Genetics of Cardiovascular Disorders, Rayne Institute, London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't