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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-1-12
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pubmed:abstractText |
The semisynthetic glycosphingolipid derivative II3Neu5-AcGgOse4-2-d-erythro-1,3-dihydroxy-2-chloro-acetamid e-4-trans- octadacene (LIGA20) attenuated injury induced by the excitotoxic L-dopa metabolite 2,4,5-trihydroxyphenylalanine (TOPA) in cultures of rat cerebellar granule cells when presented simultaneously with TOPA (EC50; 9 microM LIGA20). The natural glycosphingolipid ganglioside GM1 up to 200 microM was not neuroprotective as cotreatment, although pretreatment of cells for 2 h was efficacious. This greater potency and speed of LIGA20 action extended to limiting TOPA-induced death of cultured mesencephalic dopaminergic neurons. These data suggest that LIGA20 may have therapeutic potential for the treatment of disorders associated with excitotoxic processes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
243
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-3
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8253129-Animals,
pubmed-meshheading:8253129-Cells, Cultured,
pubmed-meshheading:8253129-Cerebellum,
pubmed-meshheading:8253129-Dihydroxyphenylalanine,
pubmed-meshheading:8253129-G(M1) Ganglioside,
pubmed-meshheading:8253129-Glycosphingolipids,
pubmed-meshheading:8253129-Neurons,
pubmed-meshheading:8253129-Parkinson Disease,
pubmed-meshheading:8253129-Rats,
pubmed-meshheading:8253129-Sphingosine
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pubmed:year |
1993
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pubmed:articleTitle |
A semisynthetic glycosphingolipid (LIGA20) reduces 2,4, 5-trihydroxyphenylalanine neurotoxicity in primary neuronal cultures.
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pubmed:affiliation |
Fidia Research Laboratories, Abano Terme, Italy.
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pubmed:publicationType |
Journal Article
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