Linked Life Data

8250894

Source:http://linkedlifedata.com/resource/pubmed/id/8250894

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-1-4
pubmed:abstractText
The importance of bone stromal cell involvement in osteoclast differentiation has been suggested. However, the detailed mechanism of its regulation is unclear. We investigated whether the soluble factors from osteoblastic cells influence osteoclast lineage cells in a population of rat bone marrow cells depleted of stromal cells. We show here that hematopoietic progenitor cells differentiate into mononuclear precursor cells, the preosteoclasts, that strongly express certain osteoclastic phenotypes in the absence of stromal cells. The multinucleation of the preosteoclasts occurred only in the presence of 1,25 dihydroxyvitamin D3 and stromal cells. The preosteoclasts themselves did not have dentine-resorbing activity, but they could differentiate into multinucleate osteoclast-like cells having such activity in the presence of rat primary osteoblasts. This culture system is a unique differentiation system for preosteoclast induction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1383-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Induction of mononuclear precursor cells with osteoclastic phenotypes in a rat bone marrow culture system depleted of stromal cells.
pubmed:affiliation
Department of Microbiology, Saga Medical School, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't