Linked Life Data

8249567

Source:http://linkedlifedata.com/resource/pubmed/id/8249567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-1-6
pubmed:abstractText
We have investigated the topography of particle-laden macrophages in the pulmonary tissue of CD-1 mice after intratracheal instillation of a suspension of 250 micrograms of calcium tungstate. The mice were sacrificed 1, 3, 7 and 14 days after the particle deposition. Lung fragments were studied by scanning electron microscopy (SEM) coupled with X-ray microanalysis that allowed in situ elemental identification of tungsten in the lungs. Tungsten-positive macrophages were distinctly located in the lungs of mice sacrificed at 1-3 days when compared with samples from mice killed 7-14 days after the calcium tungstate instillation. At 1-3 days, the tungsten-carrying macrophages were accumulated near the terminal bronchioles whereas they were seen predominantly in the alveolar ducts and sacs in the 7- to 14-day groups of mice. This suggests that during pulmonary inflammation there is a redistribution of the particle-containing macrophages throughout the deep lung tissue. In high-magnification SEM views, we observed that the tungsten-positive macrophages presented numerous surface microvilli. Tungsten-laden phagocytes were detected in interalveolar fenestrae, at the so-called Kohn pores. This finding documents that the Kohn pores may be used by inflammatory cells as a pathway for the migration of phagocytes in between adjacent alveolar sacs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5180
pubmed:author
pubmed:issnType
Print
pubmed:volume
147
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-32
pubmed:dateRevised
2007-7-2
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Morphological evidence for migration of particle-laden macrophages through the interalveolar pores of Kohn in the murine lung.
pubmed:affiliation
Department of Anatomy, Abel Salazar Institute for the Biomedical Sciences, Porto, Portugal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't