Linked Life Data

8248381

Source:http://linkedlifedata.com/resource/pubmed/id/8248381

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-1-6
pubmed:abstractText
We report two forms of visual defect in the spontaneously hypertensive rat (SHR) compared to its normotensive control strain (WKY). Ten-month-old male SHR and WKY were tested for intensity discrimination ability using a Y-maze and food reward. The SHR took more trials in the acquisition phase of the task using white light. In the test phase, in which the white light intensity difference was reduced, there was no significant difference in performance between SHR and WKY. Also, there was no significant difference between the strains when red light was used. The defect in SHR occurred in the blue range of the spectrum. Using blue light, the performance of SHR declined significantly at an intensity difference of 1.15 lux, whereas the performance of WKY did not decline significantly until the difference reached 0.01 lux. The defect in SHR for intensity discrimination was not related to cataract formation, but we detected a strain difference in the nuclei of the photoreceptor cells. Thus, this visual dysfunction may involve the rod photoreceptors. Further testing revealed a deficit in visual acuity in SHR aged 40-66 days, prior to the development of hypertension. Thus, the visual dysfunction of SHR is not secondary to their development of hypertension, but rather a discrete characteristic of the strain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
903-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Visual dysfunction in the spontaneously hypertensive rat.
pubmed:affiliation
Department of Physiology, University of New England, Armidale, N.S.W., Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't