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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-1-6
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pubmed:abstractText |
We investigated a case of graft rejection after in vivo/ex vivo T-depleted BMT in a patient who had received a HVG-matched, GVH one locus-mismatched, MLC-negative graft from his cousin. In vivo/ex vivo T cell depletion was performed with Campath 1G (CP1G) and Campath 1M (CP1M), respectively. We identified a failure of CP1G to eradicate a CDw52- (Campath-negative) host T cell population as the main cause of treatment failure. The analysis also suggests that significant host-versus-donor reactivity prior to transplant, as detected by limiting dilution analysis, also contributed to graft rejection. The rejecting T cells were bifunctional in that they showed cytotoxic activity and were capable of inhibiting haemopoietic progenitor growth by producing inhibitory lymphokines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0268-3369
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8241978-Adult,
pubmed-meshheading:8241978-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:8241978-Antigens, CD,
pubmed-meshheading:8241978-Antigens, Neoplasm,
pubmed-meshheading:8241978-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8241978-Bone Marrow Purging,
pubmed-meshheading:8241978-Bone Marrow Transplantation,
pubmed-meshheading:8241978-Cells, Cultured,
pubmed-meshheading:8241978-Combined Modality Therapy,
pubmed-meshheading:8241978-Glycoproteins,
pubmed-meshheading:8241978-Graft Rejection,
pubmed-meshheading:8241978-Humans,
pubmed-meshheading:8241978-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:8241978-Lymphocyte Activation,
pubmed-meshheading:8241978-Lymphocyte Depletion,
pubmed-meshheading:8241978-Lymphokines,
pubmed-meshheading:8241978-Male,
pubmed-meshheading:8241978-T-Lymphocyte Subsets
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pubmed:year |
1993
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pubmed:articleTitle |
Graft rejection by a population of primed CDw52- host T cells after in vivo/ex vivo T-depleted bone marrow transplantation.
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pubmed:affiliation |
Department of Internal Medicine, Ulm University Hospital, Germany.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
