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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4 Pt 2
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pubmed:dateCreated |
1993-12-1
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pubmed:abstractText |
Suckling neonatal pigs (NP, 24 h old) do not exhibit elevated blood ketone bodies (KB). Mature swine have relatively high KB under certain conditions, suggesting an ontogeny of ketogenesis. Thus we evaluated the hypothesis that NP possess a relatively attenuated ketogenic capacity vs. weaned pigs (WP) and mature pigs (MP). Fasted animals were given an intraperitoneal dose of octanoate (C8), and plasma beta-hydroxybutyrate (beta-OHB) and C8 were monitored over 180 min. Newborn (NR, 24 h old) and mature rabbits (MR, > 1 yr old) were also compared. Linear regressions of plasma beta-OHB (microM) vs. plasma C8 (microM) were calculated for C8 < 1,000 microM. There was a significant linear relationship of beta-OHB regressed against C8 in all ages of pigs (P < 0.001) and in NR (P = 0.024). The slope for NP (0.08) was one to two orders of magnitude below slopes for older pigs (WP = 1.19 and MP = 0.78, P < 0.01 vs. NP), NR *6.97, P < 0.05), and MR (4.04, NS). The beta-OHB peak in NP (40.9 +/- 4.4 microM) was 1-8% of the maxima in other animals (P < 0.05) despite a C8 maximum (2.3 +/- 0.3 mM) similar to that of WP (1.9 +/- 0.7 mM) and MR (2.9 +/- 1.2 mM) (P > 0.05, NS). The data are consistent with the hypothesis that NP have a poor capacity for ketogenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Hydroxybutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxybutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/Ketone Bodies,
http://linkedlifedata.com/resource/pubmed/chemical/Octanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/caprylic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
265
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R761-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8238444-3-Hydroxybutyric Acid,
pubmed-meshheading:8238444-Aging,
pubmed-meshheading:8238444-Animals,
pubmed-meshheading:8238444-Animals, Newborn,
pubmed-meshheading:8238444-Hydroxybutyrates,
pubmed-meshheading:8238444-Ketone Bodies,
pubmed-meshheading:8238444-Octanoic Acids,
pubmed-meshheading:8238444-Rabbits,
pubmed-meshheading:8238444-Regression Analysis,
pubmed-meshheading:8238444-Swine,
pubmed-meshheading:8238444-Weaning
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pubmed:year |
1993
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pubmed:articleTitle |
Plasma beta-hydroxybutyrate after octanoate challenge: attenuated ketogenic capacity in neonatal swine.
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pubmed:affiliation |
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign 61801.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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