| pubmed-article:8237476 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8237476 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:8237476 | lifeskim:mentions | umls-concept:C0005974 | lld:lifeskim |
| pubmed-article:8237476 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8237476 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8237476 | pubmed:dateCreated | 1993-11-26 | lld:pubmed |
| pubmed-article:8237476 | pubmed:abstractText | Particulate wear debris from bone cement or prosthetic components can stimulate macrophages to cause bone resorption in a dose-dependent manner. This bone resorption activity of particulate-stimulated macrophages is associated with increased levels of both prostaglandin E2 (PGE2) and interleukin-1 (IL-1). In this study we compared the effect of particulate size, concentration, and composition on the secretion of IL-1 and PGE2 by peritoneal macrophages and on the bone-resorbing activity of conditioned medium (CM) harvested from particulate-challenged macrophages. Particulates (titanium, Ti; polymethylmethacrylate, PMMA; and polystyrene, PS) only with phagocytosable size stimulated peritoneal macrophages to secrete IL-1 and PGE2 in a dose- and time-dependent manner. Ti particles (1-3 microns) exhibited significantly enhanced bone-resorbing activity measured as 45Ca release. The maximum bone-resorbing response was observed at a concentration of 0.1% Ti (approximately 10-15 Ti particulates per cell), which also corresponded with the highest IL-1 levels measured in particulate-challenged CM. This was measured using either conditioned media from Ti-stimulated macrophages or in cocultures of calvarial bone and macrophages in the presence of Ti. Exogenous PGE2 and recombinant human IL-1 could significantly increase the 45Ca release; indomethacin (IM) significantly reduced both the spontaneous calcium efflux and active 45Ca release from in vivo labeled calvarial bones. However, IM and/or anti-IL-1 antibodies could suppress only partly the macrophage-mediated bone resorption, indicating that, in a macrophage-bone coculture system, factors other than PGE2 and IL-1 also may regulate particulate-induced bone resorption, probably involving multiple cell types. | lld:pubmed |
| pubmed-article:8237476 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8237476 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8237476 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8237476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8237476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8237476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8237476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8237476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8237476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8237476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8237476 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8237476 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8237476 | pubmed:issn | 0884-0431 | lld:pubmed |
| pubmed-article:8237476 | pubmed:author | pubmed-author:JacobsJ JJJ | lld:pubmed |
| pubmed-article:8237476 | pubmed:author | pubmed-author:GalanteJ OJO | lld:pubmed |
| pubmed-article:8237476 | pubmed:author | pubmed-author:ValyonMM | lld:pubmed |
| pubmed-article:8237476 | pubmed:author | pubmed-author:MolnárGG | lld:pubmed |
| pubmed-article:8237476 | pubmed:author | pubmed-author:GlantT TTT | lld:pubmed |
| pubmed-article:8237476 | pubmed:author | pubmed-author:ShanbhagA SAS | lld:pubmed |
| pubmed-article:8237476 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8237476 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:8237476 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8237476 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8237476 | pubmed:pagination | 1071-9 | lld:pubmed |
| pubmed-article:8237476 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8237476 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8237476 | pubmed:articleTitle | Bone resorption activity of particulate-stimulated macrophages. | lld:pubmed |
| pubmed-article:8237476 | pubmed:affiliation | Department of Biochemistry, Rush Medical College at Rush-Presbyterian, St. Luke's Medical Center, Chicago, Illinois. | lld:pubmed |
| pubmed-article:8237476 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8237476 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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