| pubmed-article:8235656 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8235656 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:8235656 | lifeskim:mentions | umls-concept:C0043342 | lld:lifeskim |
| pubmed-article:8235656 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:8235656 | lifeskim:mentions | umls-concept:C0237477 | lld:lifeskim |
| pubmed-article:8235656 | lifeskim:mentions | umls-concept:C1621812 | lld:lifeskim |
| pubmed-article:8235656 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8235656 | pubmed:issue | 5137 | lld:pubmed |
| pubmed-article:8235656 | pubmed:dateCreated | 1993-12-21 | lld:pubmed |
| pubmed-article:8235656 | pubmed:abstractText | The natural arrest of vertebrate unfertilized eggs in second meiotic metaphase results from the activity of cytostatic factor (CSF). The product of the c-mos(xe) proto-oncogene is thought to be a component of CSF and can induce metaphase arrest when injected into blastomeres of two-cell embryos. The c-Mos(xe) protein can directly activate the mitogen-activated protein kinase kinase (MAP kinase kinase) in vitro, leading to activation of MAP kinase. MAP kinase and c-Mos(xe) are active in unfertilized eggs and are rapidly inactivated after fertilization. Microinjection of thiophosphorylated MAP kinase into one blastomere of a two-cell embryo induced metaphase arrest similar to that induced by c-Mos(xe). However, only arrest with c-Mos(xe) was associated with activation of endogenous MAP kinase. These results indicate that active MAP kinase is a component of CSF in Xenopus and suggest that the CSF activity of c-Mos(xe) is mediated by MAP kinase. | lld:pubmed |
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| pubmed-article:8235656 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8235656 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8235656 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8235656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8235656 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8235656 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8235656 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:IzumiTT | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:MallerJ LJL | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:EriksonEE | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:RoyLL | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:HartleyRR | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:HaccardOO | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:SarcevicBB | lld:pubmed |
| pubmed-article:8235656 | pubmed:author | pubmed-author:LewellynAA | lld:pubmed |
| pubmed-article:8235656 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8235656 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:8235656 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:8235656 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8235656 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8235656 | pubmed:pagination | 1262-5 | lld:pubmed |
| pubmed-article:8235656 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8235656 | pubmed:meshHeading | pubmed-meshheading:8235656-... | lld:pubmed |
| pubmed-article:8235656 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8235656 | pubmed:articleTitle | Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase. | lld:pubmed |
| pubmed-article:8235656 | pubmed:affiliation | Howard Hughes Medical Institute, University of Colorado School of Medicine, Denver 80262. | lld:pubmed |
| pubmed-article:8235656 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8235656 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8235656 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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