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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1993-12-10
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pubmed:abstractText |
We investigated the prevalence of stone disease and urinary stone risk factors in machinists chronically exposed to a hot environment and massive sweating, without interference of nephrotoxic metals or other lithogenic compounds. The study was performed at a glass plant and exposure to heat stress was estimated by the Wet Bulb Globe Temperature climatic index. The prevalence of nephrolithiasis on the entire population of the machinists was 8.5% (20 of 236), while the prevalence on the controls working in normal temperature was 2.4% (4 of 165) (p = 0.03). A high incidence (38.8%) of uric acid stones was present in the workers exposed to heat stress. Among the urinary stone risk indexes determined for 3 days during the 8-hour work shift on a randomly selected sample of 21 workers exposed and 21 workers not exposed to heat stress without any evidence of stone disease significant differences were found in uric acid concentration (722 +/- 195 versus 482 +/- 184 mg./l., p < 0.001), specific gravity (1,026 +/- 4 versus 1,021 +/- 6, p < 0.005) and pH (5.31 +/- 0.28 versus 5.64 +/- 0.54, p < 0.02), respectively. Thus, high uric acid relative supersaturation was present during occupation in hot temperatures (8.67 +/- 3.49) compared to occupation in normal temperatures (4.15 +/- 2.7) (p < 0.001). This study confirms that chronic dehydration represents a real lithogenic risk factor, mainly for uric acid stones, and adequate fluid intake is recommended during hot occupations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-5347
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1757-60
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8230496-Adult,
pubmed-meshheading:8230496-Dehydration,
pubmed-meshheading:8230496-Hot Temperature,
pubmed-meshheading:8230496-Humans,
pubmed-meshheading:8230496-Incidence,
pubmed-meshheading:8230496-Italy,
pubmed-meshheading:8230496-Kidney Calculi,
pubmed-meshheading:8230496-Male,
pubmed-meshheading:8230496-Occupational Diseases,
pubmed-meshheading:8230496-Occupational Exposure,
pubmed-meshheading:8230496-Occupations,
pubmed-meshheading:8230496-Prevalence,
pubmed-meshheading:8230496-Risk Factors,
pubmed-meshheading:8230496-Stress, Physiological,
pubmed-meshheading:8230496-Uric Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Hot occupation and nephrolithiasis.
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pubmed:affiliation |
Institute of Semeiotica Medica, University of Parma and Medicina Preventiva e Igiene del Lavoro, Parma, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
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