|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0021311,
umls-concept:C0021400,
umls-concept:C0021745,
umls-concept:C0026809,
umls-concept:C0332453,
umls-concept:C0599894,
umls-concept:C0871261,
umls-concept:C1521840,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1993-11-29
|
|
pubmed:abstractText |
Interferon gamma (IFN-gamma) is a pleiotropic cytokine secreted by T lymphocytes and natural killer (NK) cells and has been noted to be a first line of host defense in the control of viral infections. To examine further the role of this cytokine in the control of viral infections, mice with a targeted mutation in the IFN-gamma gene were infected with influenza virus, and the in vivo antibody and cell-mediated immune response to viral infection were examined. In addition, cell lines and clones were derived from the immunized animals and the in vitro cytokine production and cytotoxic T lymphocyte (CTL) response were analyzed. The absence of IFN-gamma led to increased production of influenza-specific IgG1, IL-4, and IL-5 as compared to wild-type littermate control animals. In contrast, there was no difference noted in the development of an effective CTL response between IFN-gamma-deficient and wild-type animals. In this model of experimental influenza infection, IFN-gamma is not necessary for the development of an effective humoral or cellular immune response to challenge with this respiratory virus.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-113108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-1463582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-1594596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-1830926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-1948049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2151761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2278991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2438367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2456466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2501391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2944982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-2963862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-303150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-305613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-307273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-3082972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-3125247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-3257770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-3494950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-3871453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-6166708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-6173757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-6174673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-6179076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-6206190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-6267157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-6311565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-8384701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-8426105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-8456300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8228818-8456301
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
178
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1725-32
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8228818-Animals,
pubmed-meshheading:8228818-Antibody Formation,
pubmed-meshheading:8228818-Cytotoxicity, Immunologic,
pubmed-meshheading:8228818-Female,
pubmed-meshheading:8228818-Immunity, Cellular,
pubmed-meshheading:8228818-Immunoglobulin G,
pubmed-meshheading:8228818-Immunotherapy, Adoptive,
pubmed-meshheading:8228818-Influenza A virus,
pubmed-meshheading:8228818-Interferon-gamma,
pubmed-meshheading:8228818-Interleukin-4,
pubmed-meshheading:8228818-Interleukin-5,
pubmed-meshheading:8228818-Male,
pubmed-meshheading:8228818-Mice,
pubmed-meshheading:8228818-Mice, Inbred C57BL,
pubmed-meshheading:8228818-Mice, Mutant Strains,
pubmed-meshheading:8228818-Mutagenesis,
pubmed-meshheading:8228818-Orthomyxoviridae Infections,
pubmed-meshheading:8228818-T-Lymphocytes,
pubmed-meshheading:8228818-T-Lymphocytes, Cytotoxic
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.
|
|
pubmed:affiliation |
Beirne B, Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
