Linked Life Data

8225331

Source:http://linkedlifedata.com/resource/pubmed/id/8225331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-12-9
pubmed:abstractText
The classical bidomain model of cardiac tissue views the intracellular and extracellular (interstitial) spaces as two coupled but separate continua. In the present study, the classical bidomain model has been extended by introducing a periodic conductivity in the intracellular space to represent the junctional discontinuity between abutting myocytes. In this model the junctional region of a myocyte is represented in a way that permits variation of junction size and conductivity profile. Employing spectral techniques, a new method was developed for solving the coupled differential equations governing the intracellular and extracellular potentials in a tissue preparation of finite dimensions. Different spectral representations are used for the aperiodic intra- and extracellular potentials (finite Fourier integral transform) and for the periodic intracellular conductivity (Fourier series). As a first application of the method, the response of a 50-cell, single interior fiber to a defibrillating current is examined under steady-state conditions. Transmembrane as well as intra- and extracellular potential distributions along the fiber were calculated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0018-9294
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
424-33
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
A bidomain model with periodic intracellular junctions: a one-dimensional analysis.
pubmed:affiliation
National Science Foundation/Engineering Research Center, Duke University, Durham, NC 27706.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.