Linked Life Data

8200029

Source:http://linkedlifedata.com/resource/pubmed/id/8200029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-7-1
pubmed:abstractText
IgE-binding protein (epsilon BP) is a beta-galactoside-binding animal lectin identified by its affinity for IgE. We have reported that epsilon BP also binds the mast cell high-affinity IgE receptor (Fc epsilon RI), via lectin-carbohydrate interaction. We have now studied the physiological significance of epsilon BP-IgE-Fc epsilon RI interactions in mast cell activation using rat basophilic leukemia (RBL) cells as the model system. We report here that both unsensitized and IgE-sensitized RBL cells are activated upon exposure to epsilon BP-coated surfaces. Activation of RBL cells by the lectin epsilon BP can be significantly inhibited by appropriate saccharides. Exposure of RBL cells to epsilon BP-coated surfaces caused cell spreading similar to that caused from adherence to fibronectin-coated surfaces. However, epsilon BP by itself caused mediator release whereas fibronectin only potentiated antigen-mediated activation of RBL cells. Under appropriate conditions, epsilon BP, therefore, has the potential to activate mast cells culminating in augmentation of an inflammatory response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-12
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Activation of rat basophilic leukemia cells by epsilon BP, an IgE-binding endogenous lectin.
pubmed:affiliation
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.