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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8097
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pubmed:dateCreated |
1979-1-24
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pubmed:abstractText |
51 patients with Crohn's disease who were in good health while taking azathiprine, 2 mg/kg body-weight/day, for at least six months were allocated either to a group in which azathioprine was continued or to one in which a control tablet was substituted. The trial lasted one year unless relapse recurred earlier. The cumulative probability of relapse was nil at six months and 5% (+/-5 S.D.) at a year among those on azathioprine, compared with 25% (+/-9 S.D.) at six months and 41% (+/-11 S.D.) at a year among those in the control group (P less than 0.01). 1 patient in whom azathioprine was continued died of pancytopenia in the fourth month of the trial. Azathioprine is potentially toxic but appears to reduce the relapse-rate in Crohn's disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0140-6736
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
4
|
pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
955-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:81986-Adult,
pubmed-meshheading:81986-Aged,
pubmed-meshheading:81986-Azathioprine,
pubmed-meshheading:81986-Clinical Trials as Topic,
pubmed-meshheading:81986-Crohn Disease,
pubmed-meshheading:81986-Double-Blind Method,
pubmed-meshheading:81986-Drug Evaluation,
pubmed-meshheading:81986-Female,
pubmed-meshheading:81986-Follow-Up Studies,
pubmed-meshheading:81986-Humans,
pubmed-meshheading:81986-Male,
pubmed-meshheading:81986-Middle Aged,
pubmed-meshheading:81986-Placebos,
pubmed-meshheading:81986-Recurrence,
pubmed-meshheading:81986-Remission, Spontaneous,
pubmed-meshheading:81986-Substance Withdrawal Syndrome,
pubmed-meshheading:81986-Time Factors
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pubmed:year |
1978
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pubmed:articleTitle |
Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn's disease.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|