Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-6-28
pubmed:abstractText
Successful transmission of the African trypanosome between the mammalian host blood-stream and the tsetse fly vector involves dramatic alterations in the parasite's morphology and biochemistry. This differentiation through to the tsetse midgut procyclic form is accompanied by re-entry into a proliferative cell cycle. Using a synchronous differentiation model and a variety of markers diagnostic for progress through both differentiation and the cell cycle, we have investigated the interplay between these two processes. Our results implicate a relationship between the trypanosome cell cycle position and the perception of the differentiation signal and demonstrate that irreversible commitment to the differentiation occurs rapidly after induction. Furthermore, we show that re-entry into the cell cycle in the differentiating population is synchronous, and that once initiated, progress through the differentiation pathway can be uncoupled from progress through the cell cycle.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-13785187, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-1410447, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-1474991, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-1492369, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-1496556, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-1698624, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2052026, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2188680, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2190996, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2252398, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2348830, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2555290, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2568647, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2606940, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2614608, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2645304, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-2649249, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-3194363, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-3546334, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-3670296, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-3691806, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-3743718, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-3808022, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-3928017, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-43092, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-4354962, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-5016599, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-5868887, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-6204858, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-6811596, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-8259123, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-8466914, http://linkedlifedata.com/resource/pubmed/commentcorrection/8195296-872891
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1147-56
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes.
pubmed:affiliation
Biochemistry Division, School of Biological Sciences, University of Manchester, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't