Linked Life Data

8193170

Source:http://linkedlifedata.com/resource/pubmed/id/8193170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-6-29
pubmed:databankReference
pubmed:abstractText
Expression of two subtypes of angiotensin type 1 receptor (AT1A and AT1B) seems to be controlled by different mechanisms. As a step toward the elucidation of difference in the mechanism in their gene expression, the genomic organization of rat angiotensin II type 1B receptor was investigated. Rat genomic DNA fragments were cloned by screening a genomic library with fragments from two cDNA clones (2.3 and 2.2 kb) encoding the rat AT1B receptor. Three lambda clones were isolated, and the hybridizing restriction fragments were sequenced. Comparison of the genomic clone DNA and cDNA sequences revealed that the rat AT1B receptor gene contains three exons and two introns. Two of the exons encoded 5' untranslated sequences while the third exon contained the entire coding region. The 5'-flanking region contained the typical sequence motifs found in many eukaryotic promoters including a TATA box and a potential SP1 binding site. The transcription initiation site was located at -8 bp upstream the 5' end of the cDNA in the 5'-flanking region.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
1218
pubmed:geneSymbol
AT<down>1A</down>, AT<down>1B</down>
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The genomic organization of the rat angiotensin II receptor AT1B.
pubmed:affiliation
Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.