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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-6-20
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated cDNA and genomic clones coding for the human alpha 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha 7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha 7 neuronal nicotinic subunit (90%). We have mapped the human alpha 7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:geneSymbol |
CHRNA7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
379-81
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8188270-Amino Acid Sequence,
pubmed-meshheading:8188270-Animals,
pubmed-meshheading:8188270-Base Sequence,
pubmed-meshheading:8188270-Chromosome Aberrations,
pubmed-meshheading:8188270-Chromosome Disorders,
pubmed-meshheading:8188270-Chromosome Inversion,
pubmed-meshheading:8188270-Chromosome Mapping,
pubmed-meshheading:8188270-Chromosomes, Human, Pair 15,
pubmed-meshheading:8188270-Cloning, Molecular,
pubmed-meshheading:8188270-DNA, Complementary,
pubmed-meshheading:8188270-Epilepsy,
pubmed-meshheading:8188270-Genes,
pubmed-meshheading:8188270-Humans,
pubmed-meshheading:8188270-Intellectual Disability,
pubmed-meshheading:8188270-Mice,
pubmed-meshheading:8188270-Molecular Sequence Data,
pubmed-meshheading:8188270-Rats,
pubmed-meshheading:8188270-Receptors, Nicotinic,
pubmed-meshheading:8188270-Sequence Homology, Nucleic Acid,
pubmed-meshheading:8188270-Species Specificity,
pubmed-meshheading:8188270-Syndrome
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pubmed:year |
1994
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pubmed:articleTitle |
Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7).
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pubmed:affiliation |
Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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