Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-6-16
pubmed:databankReference
pubmed:abstractText
We report the isolation of a gene encoding a novel member of the family of melanocortin receptors. The mouse melanocortin-5 receptor (mMC5R) responds to melanocortins with an increase in intracellular cyclic 3',5'-adenosine monophosphate (cAMP) concentrations. Stimulation of the mMC5R by the melanocortins revealed a hierarchy of potency in which alpha-melanocyte stimulating hormone (alpha-MSH) > beta-melanocyte stimulating hormone (beta-MSH) > adrenocorticotropic hormone (ACTH) > gamma- melanocyte stimulating hormone (gamma-MSH). Further structure-activity studies indicated that amino- and carboxyl-terminal portions of alpha-MSH appear to be key determinants in the activation of mMC5R whereas the melanocortin core heptapeptide sequence is devoid of pharmacological activity. Northern blot analysis demonstrated the expression of mMC5R mRNA in mouse skeletal muscle, lung, spleen, and brain.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
200
pubmed:geneSymbol
MCR1, MCR2, MCR3, MCR4, MCR5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1214-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8185570-Adrenocorticotropic Hormone, pubmed-meshheading:8185570-Amino Acid Sequence, pubmed-meshheading:8185570-Animals, pubmed-meshheading:8185570-Base Sequence, pubmed-meshheading:8185570-Cloning, Molecular, pubmed-meshheading:8185570-Cyclic AMP, pubmed-meshheading:8185570-DNA Primers, pubmed-meshheading:8185570-Gene Expression, pubmed-meshheading:8185570-Genes, pubmed-meshheading:8185570-Humans, pubmed-meshheading:8185570-Melanocyte-Stimulating Hormones, pubmed-meshheading:8185570-Mice, pubmed-meshheading:8185570-Molecular Sequence Data, pubmed-meshheading:8185570-RNA, Messenger, pubmed-meshheading:8185570-Rats, pubmed-meshheading:8185570-Receptors, Corticotropin, pubmed-meshheading:8185570-Receptors, Melanocortin, pubmed-meshheading:8185570-Recombinant Proteins, pubmed-meshheading:8185570-Sequence Alignment, pubmed-meshheading:8185570-Sequence Homology, Amino Acid, pubmed-meshheading:8185570-Signal Transduction
pubmed:year
1994
pubmed:articleTitle
Molecular cloning, expression, and characterization of a fifth melanocortin receptor.
pubmed:affiliation
Department of Surgery, University of Michigan Medical Center, Ann Arbor.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.