Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1994-6-6
pubmed:abstractText
We have analysed the function of sequences in the TATA/initiator region of the promoter of Ea, a class II gene of the Major Histocompatibility Complex. We find that the Ea promoter contains an initiator element with a strong influence on transcription. We also find that the Ea promoter does contain a bona fide TATA box, which can be recognized by the TATA binding protein (TBP), and that TBP is required for transcriptional activity. For activity, TBP must be included within a larger TFIID complex, as Ea transcription in a heat-treated extract can be restored by immunopurified TFIID but not by TBP alone. On the other hand, the TATA motif can be eliminated without significantly affecting either the efficiency or the startsites of transcription. This suggests that TBP, even in this TATA-containing promoter, is held in place by other components of the initiation complex, regardless of its affinity for the underlying DNA.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1380453, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1438306, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1448091, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1497921, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1547484, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1577736, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1590984, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1657708, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1729710, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1730659, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1733976, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1748279, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1821818, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1876184, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1896450, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1901896, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1907890, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1913802, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-1936986, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-2006421, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-2016543, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-2105455, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-2111709, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-2141169, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-2163345, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-2569738, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-3114745, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-3185540, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-6791577, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-8440239, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-8441620, http://linkedlifedata.com/resource/pubmed/commentcorrection/8177733-8464492
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4873-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site.
pubmed:affiliation
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l'INSERM, Faculté de Médecine, Strasbourg, France.
pubmed:publicationType
Journal Article