Linked Life Data

8169319

Source:http://linkedlifedata.com/resource/pubmed/id/8169319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-6-1
pubmed:abstractText
The potential of synthetic and natural amphetamines to modulate cellular immune effector and regulatory mechanisms was evaluated in an in vitro exposure system. Murine splenic lymphocytes and elicited peritoneal macrophages were cultured with 0.0001-100 microM of amphetamine sulfate, methamphetamine hydrochloride, or the (S) or (R) isomers of cathione hydrochloride. T-lymphocyte regulatory function was assessed by quantitating the production of cytokines, and T-lymphocyte effector function was assessed by the induction of cytotoxic T-lymphocytes (CTL). B-lymphocyte function was measured by proliferation, and natural immunity was assessed by quantitating basal and IL-2 augmented natural killer (NK) cell activity. None of the compounds tested had any direct effect on cellular viability. Exposure to amphetamine resulted in a significant suppression of IL-2, but not IL-4, production by T-lymphocytes, as well as a suppression of B-lymphocyte proliferation only at the highest amphetamine concentration examined. NK cell function was slightly suppressed by amphetamine exposure, but was enhanced by methamphetamine exposure. Conversely, exposure to either (S) or (R) isomers of cathinone resulted in stimulation of IL-2 production, B-lymphocyte proliferation, and CTL induction. No significant effect of cathione was noted on NK cell function. These data suggest that natural and synthetic amphetamines exhibit differential immunomodulatory activity following in vitro exposure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0892-3973
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-21
pubmed:dateRevised
2009-5-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Comparison of immune functional parameters following in vitro exposure to natural and synthetic amphetamines.
pubmed:affiliation
IIT Research Institute, Chicago, IL 60616.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.