Linked Life Data

8168663

Source:http://linkedlifedata.com/resource/pubmed/id/8168663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-6-1
pubmed:abstractText
The authors obtained neurological assessments and psychiatric family history data for 40 children with autistic spectrum disorders (autism, Asperger syndrome and pervasive developmental disorder). Neurological evaluation included EEG, MRI, karyotyping and positron emission tomography as indicated. Family history data were obtained from family members during long-term follow-up. 20 probands had positive neurological findings, 18 with negative family history. 14 had no neurological findings and positive family histories; they tended to have higher function. Six had neither, and two had both. The segregation of neurological findings and familial affective disorder was highly significant. These findings suggest that an important subgroup of autistic spectrum disorders may be related etiologically to familial major affective disorders, and may represent the early-life onset of a severe phenotype of major affective, particularly bipolar, disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0012-1622
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-8
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Psychiatric family history and neurological disease in autistic spectrum disorders.
pubmed:affiliation
Division of Pediatric Neurology, Duke University Medical Center, Durham, NC 27710.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't