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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0010453,
umls-concept:C0027754,
umls-concept:C0027882,
umls-concept:C0033414,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0117720,
umls-concept:C0504074,
umls-concept:C0599668,
umls-concept:C1280500,
umls-concept:C1511938,
umls-concept:C1707455
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pubmed:issue |
2
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pubmed:dateCreated |
1994-6-2
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pubmed:abstractText |
Fibroblast growth factor-5 (FGF-5) is a member of the fibroblast growth factor gene family, which has a signal sequence characteristic of secretory proteins. FGF-5 mRNA has previously been shown to be present in the adult mouse brain. Here we demonstrate that recombinant FGF-5 has neurotrophic activity on cultured rat septal cholinergic and raphe serotonergic neurons. The effect of FGF-5 on serotonin uptake was stronger than that evoked with either brain-derived neurotrophic factor or neurotrophin-3. FGF-5 also increased the choline acetyltransferase activity of cultured rat septal cholinergic neurons, the effect being additive to that of nerve growth factor. In situ hybridization experiments and immunohistochemistry using a specific anti-FGF-5 antibody demonstrated that FGF-5 is expressed in rat hippocampal neurons. Like nerve growth factor mRNA, the levels of FGF-5 mRNA in the rat hippocampus increased substantially during early postnatal development. In addition, injection of the muscarinic receptor agonist pilocarpine elevated FGF-5 mRNA. The presence of the secretory FGF-5 in the rat hippocampus, a target field of septal cholinergic and raphe serotonergic neurons, suggests that FGF-5 acts as a trophic factor for these neurons also in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Choline O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/FGF5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fgf5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fgf5 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 5,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotrophin 3,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0953-816X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-52
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8167846-Aging,
pubmed-meshheading:8167846-Animals,
pubmed-meshheading:8167846-Brain,
pubmed-meshheading:8167846-Cell Differentiation,
pubmed-meshheading:8167846-Cells, Cultured,
pubmed-meshheading:8167846-Choline O-Acetyltransferase,
pubmed-meshheading:8167846-Embryo, Mammalian,
pubmed-meshheading:8167846-Fibroblast Growth Factor 2,
pubmed-meshheading:8167846-Fibroblast Growth Factor 5,
pubmed-meshheading:8167846-Fibroblast Growth Factors,
pubmed-meshheading:8167846-Growth Substances,
pubmed-meshheading:8167846-Hippocampus,
pubmed-meshheading:8167846-Humans,
pubmed-meshheading:8167846-Male,
pubmed-meshheading:8167846-Mice,
pubmed-meshheading:8167846-Nerve Growth Factors,
pubmed-meshheading:8167846-Neurons,
pubmed-meshheading:8167846-Neurotrophin 3,
pubmed-meshheading:8167846-RNA, Messenger,
pubmed-meshheading:8167846-Raphe Nuclei,
pubmed-meshheading:8167846-Rats,
pubmed-meshheading:8167846-Rats, Wistar,
pubmed-meshheading:8167846-Recombinant Proteins,
pubmed-meshheading:8167846-Serotonin
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pubmed:year |
1994
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pubmed:articleTitle |
Fibroblast growth factor-5 promotes differentiation of cultured rat septal cholinergic and raphe serotonergic neurons: comparison with the effects of neurotrophins.
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pubmed:affiliation |
Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg-Martinsried, FRG.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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