| pubmed-article:8160837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8160837 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:8160837 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8160837 | lifeskim:mentions | umls-concept:C2265839 | lld:lifeskim |
| pubmed-article:8160837 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8160837 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:8160837 | pubmed:dateCreated | 1994-5-19 | lld:pubmed |
| pubmed-article:8160837 | pubmed:abstractText | Our objective was to investigate the direct effect of interleukin-6 (IL-6) on the vascular smooth muscle contraction. We measured the contraction of endothelium-denuded aortic rings isolated from Sprague-Dawley rats. We also investigated the involvement of vasodilator prostaglandin and guanosine 3',5'-cyclic monophosphate (cGMP) productions in the effect of IL-6 using cultured rat vascular smooth muscle cells (VSMC). Exposing the aortic rings to recombinant murine IL-6 (50 U/ml) for 180 min significantly suppressed the phenylephrine (10(-9)-10(-5) M)-induced contraction. This inhibitory effect of IL-6 on the contraction tended to exhibit a dose-dependent relationship (0.5-50 U/ml). The effect of IL-6 was totally eliminated in the presence of indomethacin (10(-5) M). The release of immunoreactive 6-ketoprostaglandin F1 alpha from cultured rat VSMC was significantly increased by exposure to IL-6. Intracellular cGMP concentration in VSMC was not affected by IL-6. In conclusion, IL-6 is a potent inhibitor of the alpha-adrenergic-stimulated contraction of vascular smooth muscle. Its action is endothelium independent and mediated by the increased synthesis of prostacyclin in VSMC. | lld:pubmed |
| pubmed-article:8160837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8160837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8160837 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8160837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8160837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8160837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8160837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8160837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8160837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8160837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8160837 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8160837 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8160837 | pubmed:author | pubmed-author:IgarashiMM | lld:pubmed |
| pubmed-article:8160837 | pubmed:author | pubmed-author:KawasakiKK | lld:pubmed |
| pubmed-article:8160837 | pubmed:author | pubmed-author:ShimadaKK | lld:pubmed |
| pubmed-article:8160837 | pubmed:author | pubmed-author:IkedaUU | lld:pubmed |
| pubmed-article:8160837 | pubmed:author | pubmed-author:KusanoEE | lld:pubmed |
| pubmed-article:8160837 | pubmed:author | pubmed-author:OhkawaFF | lld:pubmed |
| pubmed-article:8160837 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8160837 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:8160837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8160837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8160837 | pubmed:pagination | H898-902 | lld:pubmed |
| pubmed-article:8160837 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
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| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:meshHeading | pubmed-meshheading:8160837-... | lld:pubmed |
| pubmed-article:8160837 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8160837 | pubmed:articleTitle | Inhibitory effect of interleukin-6 on vascular smooth muscle contraction. | lld:pubmed |
| pubmed-article:8160837 | pubmed:affiliation | Department of Community and Family Medicine, Jichi Medical School, Tochigi, Japan. | lld:pubmed |
| pubmed-article:8160837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8160837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8160837 | lld:pubmed |
