rdf:type |
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0013819,
umls-concept:C0022655,
umls-concept:C0025219,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0039476,
umls-concept:C0249681,
umls-concept:C0699864,
umls-concept:C1280500,
umls-concept:C1442792,
umls-concept:C2827424,
umls-concept:C2917356
|
pubmed:issue |
1
|
pubmed:dateCreated |
1994-5-19
|
pubmed:abstractText |
The effects of melatonin (3 mg/kg i.p.) and the melatonin receptor agonist S-20098 (3 mg/kg i.p.) on the vigilance states, electroencephalogram power spectra (0.25-25.0 Hz), and cortical temperature were determined in eight rats in the first 6-hr interval of the 12-hr light period. Compared to the vehicle injection both compounds reduced the power density in non-rapid eye movement sleep in the low frequency range (1-8 Hz) but did not affect the vigilance states and brain temperature. The present findings do not indicate that the stimulation of the melatonin receptor exerts a hypnotic effect at doses that had been shown to affect the circadian rest-activity rhythm.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0742-3098
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
26-32
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8158520-Acetamides,
pubmed-meshheading:8158520-Animals,
pubmed-meshheading:8158520-Arousal,
pubmed-meshheading:8158520-Body Temperature,
pubmed-meshheading:8158520-Cerebral Cortex,
pubmed-meshheading:8158520-Electroencephalography,
pubmed-meshheading:8158520-Male,
pubmed-meshheading:8158520-Melatonin,
pubmed-meshheading:8158520-Rats,
pubmed-meshheading:8158520-Rats, Sprague-Dawley,
pubmed-meshheading:8158520-Receptors, Cell Surface,
pubmed-meshheading:8158520-Receptors, Melatonin
|
pubmed:year |
1994
|
pubmed:articleTitle |
Effects of melatonin and the melatonin receptor agonist S-20098 on the vigilance states, EEG spectra, and cortical temperature in the rat.
|
pubmed:affiliation |
Institute of Pharmacology, University of Zürich, Switzerland.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|