Linked Life Data

8157124

Source:http://linkedlifedata.com/resource/pubmed/id/8157124

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-5-16
pubmed:abstractText
Following facial nerve injury, female hamster facial motoneurons (HFMN) regenerate faster than their male counterparts. Testosterone propionate (TP) markedly accelerates the rate of facial nerve regeneration in males, but has a relatively reduced effect in females. In the present study, we utilized in situ hybridization in conjunction with ribosomal DNA probes to test the hypothesis that in females HFMN axotomy produces a less dramatic cell body response than in males and to examine gender differences in the effects of steroids on peripheral nerve regeneration at the molecular level. The results indicate that in females axotomy alone induced moderate increases in rRNA levels, beginning 2 days postoperatively. These changes were both slower in onset and lower in magnitude than those in the males. TP augmented the effects of axotomy on rRNA levels at the later postoperative times. There were no early, rapid effects of TP, like those observed in males. These molecular data substantiate our previous findings of inherent sex differences in neuronal regeneration and the ability of gonadal steroids to augment the reparative response of peripheral neurons to injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
144-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Axotomy-induced changes in ribosomal RNA levels in female hamster facial motoneurons: differential effects of gender and androgen exposure.
pubmed:affiliation
Department of Physical Therapy, University of Illinois at Chicago 60612.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.