Linked Life Data

815433

Source:http://linkedlifedata.com/resource/pubmed/id/815433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-6-2
pubmed:abstractText
The action of immune sera from animals with chronic Chagas disease on Trypanosoma cruzi bloodstream forms (Y and CL strains) was investigated. Y strain trypomastigotes were agglutinated by anti-CL or anti-Y immune sera and their infectivity was decreased when inoculated into normal mice. CL strain trypomastigotes, however, remained apparently unchanged, with neither agglutination nor decline of infectivity being observed after incubation with both immune sera. Sera from three patients with chronic Chagas disease clearly agglutinated and two of them decreased the infectivity of Y strain trypomastigotes. Passive transfer of immunity was achieved in mice that recieved anti-CL or anti-Y immune sera and that were challenged with Y strain parasites. These results suggest that humoral immunity participates in the protective immune response against T. cruzi and that bloodstream trypomastigotes represent a more suitable model for studies of antigenic variation in these infections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
755-60
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Protective effects of specific antibodies in Trypanosoma cruzi infections.
pubmed:publicationType
Journal Article