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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1994-5-12
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pubmed:databankReference |
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pubmed:abstractText |
Sendai virus fresh isolates were shown to be antigenically different from the prototype Fushimi strain that had long been passaged in embryonated chicken eggs. Phylogenetic analysis of the hemagglutinin-neuraminidase genes also revealed the difference between these two virus groups. Both trypsin-resistant and elastase-sensitive mutations were additionally introduced to an LLC-MK2-cell-adapted and attenuated mutant derived from one of the fresh isolates. This protease activation mutant (MVCES1) showed the same antigenicity as the fresh isolates, and as a result of a single cycle of growth in lungs, it could confer better protection on mice against challenge infection with the currently prevailing Sendai virus than TR-5, which is a trypsin-resistant mutant derived from the Fushimi strain. The eligibility of MVCES1 as an attenuated live vaccine of Sendai virus is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-1311131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-1326808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-1331518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-16073430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-1618859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-174294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-181619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-202799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-208971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2161155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2170692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2173829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-219669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2824671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2836627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2841801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2846765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2981341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2981971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-2986845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-3027971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-3035279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4304326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4325227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4332134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4337168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4353216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4353954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4357516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4361457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-4369772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-5101090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-6153234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-6244963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-6247399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-6247622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-6299951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-6300994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-6314932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-8380186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8151795-948870
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3369-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8151795-Amino Acid Sequence,
pubmed-meshheading:8151795-Animals,
pubmed-meshheading:8151795-Endopeptidases,
pubmed-meshheading:8151795-Hemagglutinins, Viral,
pubmed-meshheading:8151795-Mice,
pubmed-meshheading:8151795-Mice, Inbred BALB C,
pubmed-meshheading:8151795-Molecular Sequence Data,
pubmed-meshheading:8151795-Mutation,
pubmed-meshheading:8151795-Parainfluenza Virus 1, Human,
pubmed-meshheading:8151795-Paramyxoviridae Infections,
pubmed-meshheading:8151795-Safety,
pubmed-meshheading:8151795-Sequence Homology, Amino Acid,
pubmed-meshheading:8151795-Vaccination,
pubmed-meshheading:8151795-Vaccines, Attenuated,
pubmed-meshheading:8151795-Viral Fusion Proteins,
pubmed-meshheading:8151795-Viral Vaccines
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pubmed:year |
1994
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pubmed:articleTitle |
A protease activation mutant, MVCES1, as a safe and potent live vaccine derived from currently prevailing Sendai virus.
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pubmed:affiliation |
Department of Microbiology, Kobe University School of Medicine, Japan.
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